abstract：:32P-Postlabeling analysis and enzyme-linked immunosorbent assay (ELISA) have been used to detect DNA adducts in peripheral blood lymphocytes from primary aluminum production plant workers who were exposed occupationally to a mixture of polycyclic aromatic hydrocarbons (PAHs). Preliminary results reported here are from...

journal_title：Environmental health perspectives

authors： Schoket B,Phillips DH,Poirier MC,Vincze I

更新日期：1993-03-01 00:00:00

abstract：:Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we measured PAH-DNA adducts by enzyme-linked immunosorbent assay in WBCs obtained from 47 California wildland (forest) fire...

journal_title：Environmental health perspectives

authors： Rothman N,Poirier MC,Haas RA,Correa-Villasenor A,Ford P,Hansen JA,O'Toole T,Strickland PT

更新日期：1993-03-01 00:00:00

abstract：:Tobacco smoke contains a number of genotoxic compounds that are metabolized to their biologically active forms that subsequently react with cellular DNA to form covalently bound carcinogen-DNA adducts. Several analytical procedures have been developed to detect these adducts in human tissues. Using the nuclease P1-enh...

journal_title：Environmental health perspectives

authors： Hansen C,Asmussen I,Autrup H

更新日期：1993-03-01 00:00:00

abstract：:Hemoglobin adducts of the common metabolite of the tobacco-specific nitrosamine (TSNA) 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and of 4-aminobiphenyl (4-ABP) were quantified in blood samples from smokers and nonsmokers to test their suitability for biomonitoring tobacco smoke exposure. Additionally, TSNA adducts were...

journal_title：Environmental health perspectives

authors： Schäffler G,Betz C,Richter E

更新日期：1993-03-01 00:00:00

abstract：:Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids and proteins, and the carcinogenicity of 10 of these HAs in rodents and of 1 in monkeys has been reported. Quantification of these carcinogenic HAs in various kinds of cooked foods indicated that the level of 2...

journal_title：Environmental health perspectives

authors： Wakabayashi K,Ushiyama H,Takahashi M,Nukaya H,Kim SB,Hirose M,Ochiai M,Sugimura T,Nagao M

更新日期：1993-03-01 00:00:00

abstract：:Perinatal exposure to carcinogens may contribute to the determination of susceptibility to cancer in two situations: a) exposure in utero of embryonal or fetal somatic cells to carcinogens, and b) prezygotic exposure of the germ cells of one or both parents to carcinogens. Epidemiological as well as experimental studi...

journal_title：Environmental health perspectives

authors： Yamasaki H,Loktionov A,Tomatis L

更新日期：1992-11-01 00:00:00

abstract：:The role of lime in the formation of reactive oxygen species (ROS), i.e., O2-., H2O2, and OH., from betel-quid components (extracts of areca nut and catechu) was investigated in vitro using a chemiluminescence technique and an assay for oxidative DNA damage involving analysis of 8-hydroxy-2'-deoxyguanosine. Of the var...

journal_title：Environmental health perspectives

authors： Nair UJ,Obe G,Friesen M,Goldberg MT,Bartsch H

更新日期：1992-11-01 00:00:00

abstract：:The accumulation of genetic damage in the forms of activated proto-oncogenes and inactivated tumor-suppressor genes is the driving force in the evolution of a normal cell to a malignant cell. For example, both the activation of ras oncogenes and the inactivation of several suppressor genes, including p53, have been ob...

journal_title：Environmental health perspectives

authors： Anderson MW,Reynolds SH,You M,Maronpot RM

更新日期：1992-11-01 00:00:00

abstract：:Repeated inhalation of silica dust can lead to inflammation and fibrosis in human lung and in experimental animal models. The alveolar macrophage is believed to play a pivotal role in this process. Numerous macrophage-derived growth factors, cytokines, and arachidonic acid metabolites have been shown to contribute to ...

journal_title：Environmental health perspectives

authors： Koren HS,Joyce M,Devlin RB,Becker S,Driscoll K,Madden MC

更新日期：1992-07-01 00:00:00

abstract：:For workers in the nuclear industry, the primary route for the entry of radioactive materials into the body is by inhalation, and the rate of clearance of particles from the pulmonary region of the lung is an important factor in determining radiation dose. It is the function of alveolar macrophages (AM) to maintain th...

journal_title：Environmental health perspectives

authors： Kellington JP,Gibson K,Buckle TM,Talbot RJ,Hornby SB

更新日期：1992-07-01 00:00:00

abstract：:Hamsters were exposed to an aerosol of fused aluminosilicate particles (FAP) labeled with 57Co. Three groups of animals were given bronchopulmonary lavage, beginning at either 1 week, 1 month, or 6 months after exposure. Each treated group was lavaged eight times over a period of 25 days. Each lavage involved 10 salin...

journal_title：Environmental health perspectives

authors： Ellender M,Hodgson A,Wood KL,Moody JC

更新日期：1992-07-01 00:00:00

abstract：:The lysosomes of several varieties of cells such as the tubular proximal cell of the kidney and the alveolar macrophage have the ability to concentrate and precipitate several elements inhaled in water-soluble form, usually as phosphate. The mechanism involved is attributed to the high acid phosphatase activity of lys...

journal_title：Environmental health perspectives

authors： Galle P,Berry JP,Galle C

更新日期：1992-07-01 00:00:00

abstract：:In this paper we give some examples of using databases of genotoxicity and carcinogenicity for quantitative and qualitative correlation studies between short-term tests and carcinogenicity. The quality of the databases is obviously important, but one of the major deficiencies of present databases is that they are too ...

journal_title：Environmental health perspectives

authors： Parodi S,Malacarne D,Taningher M

更新日期：1991-12-01 00:00:00

abstract：:A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the mutagenicity of the PAH...

journal_title：Environmental health perspectives

authors： Bolsaitis PP,Feitelberg AS,Dekermendjian V,Elliott JF,Sarofim AF,Thilly WG

更新日期：1991-12-01 00:00:00

abstract：:Worldwide climate change and loss of biodiversity are issues of global scope and importance that have recently become subjects of considerable public concern. Unlike classical public health issues and many environmental issues, their perceived threat lies in their potential to disrupt ecological functioning and stabil...

journal_title：Environmental health perspectives

authors： Jutro PR

更新日期：1991-12-01 00:00:00

abstract：:The genetic toxicology databases for chemicals that have been tested extensively are generally composed of inconsistent responses from a diverse set of assays. Consequently, difficulties arise when the data are evaluated for classifying the agent or for assessing the chemical's hazard potential. Several years ago, the...

journal_title：Environmental health perspectives

authors： Brusick D

更新日期：1991-12-01 00:00:00

abstract：:Building-related illness ranges from mild rhinitis to potentially life-threatening hypersensitivity pneumonitis and legionellosis. Sick-building syndrome, consisting of headache, mucous membrane irritation, and fatigue, may be present in 30% of all office workers. Hypersensitivity pneumonitis, asthma, and legionellosi...

journal_title：Environmental health perspectives

authors： Welch LS

更新日期：1991-11-01 00:00:00

abstract：:The carcinogenic properties of selected metals and their compounds are reviewed to provide a useful reference for existing knowledge on relationships between physical and chemical forms, kinetics and carcinogenic potential and between epidemiology, bioassays, and short-term tests. Extensive consideration is given to a...

journal_title：Environmental health perspectives

authors： Magos L

更新日期：1991-11-01 00:00:00

abstract：:Under a cooperative agreement between New York University and the Environmental Protection Agency, and in collaboration with the University of Sao Paulo (USP), a study is ongoing in Cubatao, Brazil, to try to establish exposure-response relationships on the impact of specific industrial effluents on respiratory functi...

journal_title：Environmental health perspectives

authors： Spektor DM,Hofmeister VA,Artaxo P,Brague JA,Echelar F,Nogueira DP,Hayes C,Thurston GD,Lippmann M

更新日期：1991-08-01 00:00:00

abstract：:Nitrate contamination of drinking water implies a genotoxic risk to man due to the endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite. Thus far, epidemiological studies have presented conflicting results on the relation of drinking water nitrate levels with gastric cancer incidence. ...

journal_title：Environmental health perspectives

authors： Kleinjans JC,Albering HJ,Marx A,van Maanen JM,van Agen B,ten Hoor F,Swaen GM,Mertens PL

更新日期：1991-08-01 00:00:00

abstract：:Serious problems emerge when evaluating evidence on lead neurotoxicity in children. The extent of these problems and ways to control them were explored in a study of 1291 children from the first class in the schools of Aarhus municipality, Denmark. The lead retention in circumpulpal dentin in shed deciduous teeth was ...

journal_title：Environmental health perspectives

authors： Grandjean P,Lyngbye T,Hansen ON

更新日期：1991-08-01 00:00:00

abstract：:Restriction-fragment-length polymorphism analysis was performed on several different types of human cancers, including carcinoma of the uterine cervix, neuroblastoma, hepatocellular carcinoma, pheochromocytoma, stomach cancer, and small-cell lung carcinoma (SCLC), to determine the chromosomal loci of putative tumor-su...

journal_title：Environmental health perspectives

authors： Yokota J,Sugimura T,Terada M

更新日期：1991-06-01 00:00:00

abstract：:Okadaic acid, dinophysistoxin-1 (35-methylokadaic acid), and calyculin A are the okadaic acid class of non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters, which do not bind to the phorbol ester receptors in cell membranes or activate protein kinase C in vitro. They have potent tumor-promoting activiti...

journal_title：Environmental health perspectives

authors： Fujiki H,Suganuma M,Yoshizawa S,Nishiwaki S,Winyar B,Sugimura T

更新日期：1991-06-01 00:00:00

abstract：:Current research indicates a role for several oncogenes in radiation-induced carcinogenesis in vivo and cell transformation in vitro. Certain oncogenes are probably also involved in some cases of human cancer caused by exposure to nonionizing radiation and may play a mechanistic role in the phenomenon of radioresistan...

journal_title：Environmental health perspectives

authors： Garte SJ,Burns FJ

更新日期：1991-06-01 00:00:00

abstract：:There is accumulating evidence that the multistage carcinogenic process is associated with the progressive acquisition of mutations in cellular proto-oncogenes and in growth-suppressor genes. At the same time, several types of evidence indicate that nongenotoxic agents and epigenetic events also play an important role...

journal_title：Environmental health perspectives

authors： Weinstein IB

更新日期：1991-06-01 00:00:00

abstract：:A literature review of experimental and human exposure studies of skin permeation and cutaneous hypersensitivity reactions evoked by chromium was carried out to provide a basis for making a risk assessment of chromium as a soil contaminant. In vitro and in vivo studies demonstrated that 1 to 4% of the applied dose of ...

journal_title：Environmental health perspectives

authors： Bagdon RE,Hazen RE

更新日期：1991-05-01 00:00:00

abstract：:The types of reactive intermediates generated upon reduction of chromium(VI) by glutathione or hydrogen peroxide and the resulting DNA damage have been determined. In vitro, reaction of chromium(VI) with glutathione led to formation of two chromium(V) complexes and the glutathione thiyl radical. When chromium(VI) was ...

journal_title：Environmental health perspectives

authors： Aiyar J,Berkovits HJ,Floyd RA,Wetterhahn KE

更新日期：1991-05-01 00:00:00

abstract：:This article summarizes the basic facts about the measurement of ionizing radiation, usually referred to as radiation dosimetry. The article defines the common radiation quantities and units; gives typical levels of natural radiation and medical exposures; and describes the most important biological effects of radiati...

journal_title：Environmental health perspectives

authors： Cameron J

更新日期：1991-02-01 00:00:00

abstract：:Lead-induced nephropathy produces both tubular and interstitial manifestations of cell injury, but the pathophysiology of these lesions is not completely understood. Delineation of the molecular factors underlying renal handling of lead is one of central importance in understanding the mechanisms of renal cell injury ...

journal_title：Environmental health perspectives

authors： Fowler BA,DuVal G

更新日期：1991-02-01 00:00:00

abstract：:As part of a cohort study of the effects of chronic exposure to lead on pregnancy outcome and child development, lead concentrations in the umbilical cord and placental tissues (body and membranes) from 9 late fetal deaths, 23 preterm births, and 18 births associated with premature rupture of the amniotic membranes we...

journal_title：Environmental health perspectives

authors： Baghurst PA,Robertson EF,Oldfield RK,King BM,McMichael AJ,Vimpani GV,Wigg NR

更新日期：1991-01-01 00:00:00

abstract：:To further the development and application of exposure markers in field investigations in reproductive epidemiology, we have synthesized recent examinations of the issues surrounding exposure measurements in reproductive epidemiology. The specific goals of this paper are to define exposure biomarkers and explore their...

journal_title：Environmental health perspectives

authors： Hogue CJ,Brewster MA

更新日期：1991-01-01 00:00:00

abstract：:The Clean Air Act requires that sensitive subgroups of exposed populations be protected from adverse health effects of air pollution exposure. Hence, data suggesting the existence of sensitive subgroups can have an important impact on regulatory decisions. Some investigators have interpreted differences among individu...

journal_title：Environmental health perspectives

authors： Brunekreef B,Kinney PL,Ware JH,Dockery D,Speizer FE,Spengler JD,Ferris BG Jr

更新日期：1991-01-01 00:00:00

abstract：:Fish and shellfish caught in polluted waters contain potentially dangerous amounts of toxic and carcinogenic chemicals. Public concern was heightened when a large percentage of winter flounder taken from Boston Harbor was found to have visible cancer of the liver; winter flounder outside the estuary area had no liver ...

journal_title：Environmental health perspectives

authors： Huff J,Bucher J,Yang R

更新日期：1991-01-01 00:00:00

abstract：:Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when ...

journal_title：Environmental health perspectives

authors： Bombi GG,Corain B,Favarato M,Giordano R,Nicolini M,Perazzolo M,Tapparo A,Zatta P

更新日期：1990-11-01 00:00:00

abstract：:A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning. Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls. Lesions were characterized by the appearance of edema and epithelial...

journal_title：Environmental health perspectives

authors： Roncero V,Vincente JA,Redondo E,Gãzquez A,Duran E

更新日期：1990-11-01 00:00:00

abstract：:Five decades ago, lead toxicity in childhood was thought in nonlethal cases to be without residual effect. This misconception was corrected in 1943 by Randolph Byers, who began the modern era of lead neurotoxicology by asserting that lead not only killed cells, but interfered with the normal development of central ner...

journal_title：Environmental health perspectives

authors： Needleman HL

更新日期：1990-11-01 00:00:00

abstract：:Prostaglandin-H synthase is unique among enzymes of the plant and animal kingdom in its ability to biosynthesize and metabolize hydroperoxides. Its cyclooxygenase activity oxygenates polyunsaturated fatty acids to hydroperoxy endoperoxides, and its peroxidase activity reduces the hydroperoxy group to hydroxy groups. H...

journal_title：Environmental health perspectives

authors： Marnett LJ

更新日期：1990-08-01 00:00:00

abstract：:Parental occupational exposures might affect childhood cancer in the offspring through genetic changes in the ovum or sperm or through transplacental carcinogenesis. The 24 published epidemiologic studies of this association have all used case-control designs, with controls generally selected from birth certificates o...

journal_title：Environmental health perspectives

authors： Savitz DA,Chen JH

更新日期：1990-08-01 00:00:00

abstract：:The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c ...

journal_title：Environmental health perspectives

authors： Dippold W,Steinborn A,Meyer zum Büschenfelde KH

更新日期：1990-08-01 00:00:00

abstract：:Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitative are also the least relevant in terms...

journal_title：Environmental health perspectives

authors： Hall EJ,Hei TK

更新日期：1990-08-01 00:00:00